Targeting Heightened Inflammatory Tone in IUGR Neonatal Lambs via Daily Oral Supplementation of ω-3 PUFA Improved Growth Rates, Muscle Mass, and Adiponectin Signaling.

ABSTRACT: Background/Objectives: Circulating inflammatory cytokines and tissue sensitivity are both elevated following heat stress-induced intrauterine growth restriction (IUGR). Cytokines disrupt myoblast function and muscle growth, and thus we hypothesized that suppressing inflammatory tone in IUGR-born lambs by supplementing anti-inflammatory nutraceuticals would improve early postnatal growth. Methods: IUGR lambs produced by maternal heat stress were supplemented daily with 42 mg/kg oral omega-3 polyunsaturated fatty acid (ω-3 PUFA) Ca²⁺ salts or placebo from birth to 28 days of age. Results: By day 28, the 21% lighter bodyweights for IUGR lambs were fully resolved by ω-3 PUFA due to the complete recovery of average daily gain. Subcutaneous fat deposition and visc

SUBMITTER: White MR 

PROVIDER: S-EPMC12942730 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature