Topological and Functional Diversity of Gut Microbiota Metabolism Across the Human Lifespan.

ABSTRACT: Background: The human gut microbiota plays a central role in host physiology by influencing digestion, immune function, and metabolism. Characterizing age-associated differences in the organization of microbial metabolism may provide insights into functional variation in the gut microbiome across the human lifespan. Methods: Gut microbiota metabolic organization was analyzed in a cohort of 30 individuals spanning three age groups (infants, adults, and elderly individuals) and comprising 156 stool samples. Community metabolic networks were reconstructed using the metabolic Directed Acyclic Graph (m-DAG) framework derived from KEGG Ortholog annotations. Network topology was characterized to assess whether the resulting networks conform to previously described global structural

SUBMITTER: Perez-Rocher B 

PROVIDER: S-EPMC12942874 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature