Untargeted Metabolomics Profiling of a PFAS-Exposed Flemish Population.

ABSTRACT: Background/Objectives: Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants that accumulate in humans through everyday exposure pathways, raising concern about long-term metabolic health effects in exposed populations. This study aimed to characterize PFAS-associated serum metabolic alterations in a Flemish population residing within a 3 km radius of a PFAS production facility using untargeted metabolomics and lipidomics. Methods: A cohort of 82 adults was stratified into high-exposure (n = 41, median total PFAS = 162.0 ng/mL) and low-exposure (n = 41, median total PFAS = 7.2 ng/mL) groups. Serum metabolic profiling was performed using four liquid chromatography-high-resolution mass spectrometry (LC-HRMS)-based platforms. Univariate

SUBMITTER: Delgado-Povedano MDM 

PROVIDER: S-EPMC12943362 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature