Sixty Years After a Coal Mine Disaster: Serum Metabolomic Profiles in Older Adults with Long-Term Sequelae of Carbon Monoxide Poisoning: A Cross-Sectional Study.

ABSTRACT:

Background

Survivors with chronic sequelae of carbon monoxide (CO) poisoning after the 1963 Miike-Mikawa coal mine disaster can exhibit persistent higher brain dysfunction in late life. We examined whether serum metabolic alterations remained detectable ~60 years later and assessed serum brain-derived neurotrophic factor (BDNF).

Methods

In this cross-sectional case-control study, outpatients with chronic CO-poisoning sequelae (CO; n = 14) and former miners without CO exposure (CON; n = 16), all aged ≥ 75 years, underwent targeted serum metabolomics (1183 metabolites) and clinical assessments. Between-group differences were evaluated using Welch's t-test, and age-matched propensity-score matching (1:1) served as a sensitivity analysis. BDNF was additionally compared us

SUBMITTER: Baba E 

PROVIDER: S-EPMC12943369 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature