Elaboration of a prognostic model associated with retinal hemorrhage in hemophagocytic lymphohistiocytosis.

ABSTRACT:

Background

This retrospective case-control study focused on retinal hemorrhage associated with hemophagocytic lymphohistiocytosis (HLH), integrating various ocular examination parameters to investigate the survival and prognostic factors in HLH patients.

Methods

Of 1973 assessed patients, 104 were finally recruited and 1:1 matched into retinal hemorrhage and control groups, with the hemorrhage area further graded in the former. Demographic and hematological data were collected; central, inner, outer retinal thickness and choroidal vascularity index (CVI) were measured via optical coherence tomography (OCT). Cox proportional hazards regression models (CoxPH) were elaborated, followed by bootstrapping internal validation and external validation.

Results

The hemorrhage g

SUBMITTER: Tian H 

PROVIDER: S-EPMC12943805 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature