Clinical impact of chronic pulmonary aspergillosis in patients with pulmonary nontuberculous mycobacterial disease and colonization: a multicentre prospective cohort study.

ABSTRACT:

Background

Pulmonary nontuberculous mycobacterial (NTM) infection and chronic pulmonary aspergillosis (CPA) are interconnected diseases, but their relationship remains poorly understood.

Materials and methods

In this prospective, multi-centre study conducted in Taiwan between August 2020 and January 2024, 365 patients with cultures positive for Mycobacterium avium complex, Mycobacterium kansasii, or Mycobacterium abscessus complex were followed until August 2024. Serum Aspergillus-specific IgG levels were measured at baseline and follow-up.

Results

Among these patients, 123 (33.7%) tested positive for Aspergillus-specific IgG (>40 mgA/L), and 33 (9.0%) were diagnosed with CPA (10 at initial diagnosis, 23 developed CPA during a median

SUBMITTER: Lee MR 

PROVIDER: S-EPMC12943816 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature