Association between hypothermic machine perfusion parameters and graft function in deceased donor kidney transplantation.

ABSTRACT:

Background

Kidney transplantation (KT) is the most effective treatment for end-stage renal disease. Hypothermic machine perfusion (HMP) can improve renal energy metabolism and reduce ischemia-reperfusion injury compared with static cold storage. This study aimed to evaluate the association between HMP parameters and graft function in deceased donor kidney transplantation (DDKT) and to develop a predictive model for early risk stratification.

Methods

A retrospective analysis was conducted on 2,041 DDKT recipients from 1 January 2015 to 30 June 2023. The primary outcome, delayed graft function (DGF), was defined as the need for at least one dialysis session within the first week after transplantation. Consensus clustering (CC) and restricted cubic spline (RCS) analysis were us

SUBMITTER: Dong B 

PROVIDER: S-EPMC12943820 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature