Development and validation of interpretable multimodal clinical-radiomics models for predicting epileptogenic foci and surgical outcomes in tuberous sclerosis complex: A multicenter study.

ABSTRACT: Precise localization and resection of epileptogenic (epi) foci from multiple cortical foci determine surgical outcomes in the tuberous sclerosis complex (TSC). Although the use of intracranial electroencephalography (EEG) for detecting epileptic discharges remains the gold standard for identifying epi foci, its invasiveness and cost limit clinical application. We aimed to develop and validate a noninvasive, clinically applicable predictive model for epi foci identification and surgical outcome assessment in patients with TSC. This multicenter study focused on three retrospective cohorts and one prospective cohort from three comprehensive epilepsy centers from June 2013 to October 2024. Comprehensive clinical and imaging data (CT, MRI, and 18F-FDG PET) of cortical foci were collected. Ninet

SUBMITTER: Li Y 

PROVIDER: S-EPMC12944716 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature