Effect of Self-Assembling Peptide on White Spot Lesions in Orthodontic Patients: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Objective: To evaluate the effect of self-assembling peptide (SAP) on white spot lesions (WSLs) in orthodontic patients with fixed appliances.

Methods

Eligibility Criteria: Randomized and non-randomized clinical studies, as well as in vitro studies, comparing SAP with fluoride or no treatment for WSLs in orthodontic patients were included. Outcomes assessed were WSL score, lesion size, or fluorescence loss. Case reports, case series, animal studies, and narrative reviews were excluded.

Information sources

Comprehensive literature search of six databases was conducted up to May 16, 2025. Risk of Bias: Risk of bias was assessed using tools appropriate to each study design: RoB-2 for randomized controlled trials, ROBINS-I for non-randomized studies, and QUIN f

SUBMITTER: Shakir S 

PROVIDER: S-EPMC12944740 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature