Effects of tacrolimus treatment on the gut microbiota and metabolites in liver transplant recipients.

ABSTRACT:

Background

Liver transplantation (LT) is an effective treatment for patients with end-stage liver disease. In recent years, more and more evidence has supported the association between gut microbiota dysbiosis and the pathogenesis and progression of liver diseases.

Methods

The study included 36 patients who received tacrolimus treatment after liver transplantation. Patients were stratified into subgroups according to three key variables: tacrolimus treatment duration, whole-blood tacrolimus concentration, and tacrolimus concentration-to-dose (C/D) ratio. Fecal samples and whole-blood specimens were collected from all participants. The Illumina HiSeq X platform was used to detect the gut metagenome, analyzing the composition and characteristics of the gut microbiota. Liquid c

SUBMITTER: Wang G 

PROVIDER: S-EPMC12944773 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature