Attenuating effects of inflammatory pathway by prolonged left ventricular unloading after myocardial infarction in male rats.

ABSTRACT:

Background

Inflammatory response plays a pivotal role in myocardial injury and post-infarction remodeling after acute myocardial infarction (AMI). Mechanical unloading (UL) of the left ventricle (LV) has been proposed as a potential therapeutic strategy to preserve cardiac function; however, its effects on myocardial inflammation remain incompletely understood.

Methods

We employed a rat model of partial UL using heterotopic heart-lung transplantation following AMI. RNA sequencing (RNA-seq) was performed to evaluate transcriptomic changes, with a specific focus on inflammatory pathways in the non-infarcted remote area. Immune cell abundance was estimated using deconvolution analysis (QUANTISEQ). Quantitative PCR was performed to analyze some inflammatory cytokines, and macrop

SUBMITTER: Gao J 

PROVIDER: S-EPMC12944788 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature