GDBIG: A Pioneering Birth Cohort Genomic Platform Facilitating Intergenerational Genetic Research.

ABSTRACT: High-quality genome databases derived from large-scale, family-based birth cohorts are vital resources for investigating the genetic determinants of early-life traits and the impact of early-life environments on the health of both parents and offspring. Here, we established a genomic platform for the Born in Guangzhou Cohort Study (BIGCS), the Genome Database of BIGCS (GDBIG), which represents the first birth cohort-based genomic database in China and is designed to facilitate intergenerational genetic research. Based on the phase I results of the BIGCS, GDBIG includes low-coverage (∼ 6.63×) whole-genome sequencing (WGS) data and extensive pregnancy phenotypes from 4053 Chinese participants. These participants are from 30 of China's 34 provincial-level administrative divisions, encompassin

SUBMITTER: Huang S 

PROVIDER: S-EPMC12944825 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature