Chronic Kidney Disease-Associated Defect in Humoral Immune Response Is Driven by Inflammation.

ABSTRACT: Advanced chronic kidney disease (CKD) is associated with impaired humoral immunity, contributing to increased infection-related mortality and suboptimal vaccine responses, as notably observed during the COVID-19 pandemic. CKD is also marked by the accumulation of uremic toxins, but whether they directly influence T and B cell functionality remains unclear. In this translational study, we integrated clinical and biological data from 106 CKD patients with mechanistic insights from in vitro and in vivo murine models to identify the mechanisms underlying CKD-associated defects in humoral responses against T cell-dependent antigens. Contrary to our initial hypothesis, indoxyl sulfate-despite its known ability to activate Aryl hydrocarbon Receptor signaling in monocytes-did not directly impair T

SUBMITTER: Espi M 

PROVIDER: S-EPMC12944840 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature