Integrated Composition-Toxicity Assessment Reveals Seasonal Drivers of PM_2.5 Health Risks in Hefei, China.

ABSTRACT: Amidst rapid urbanization, fine particulate matter (PM_2.5) has emerged as a critical environmental challenge in China, posing substantial health risks due to its complex composition and diverse sources. This study provides a seasonally resolved analysis of PM_2.5 composition and multi-faceted toxicity in Hefei, a major Chinese manufacturing center. PM_2.5 samples collected across four seasons were chemically characterized for water-soluble ions, carbonaceous components, metals, and polycyclic aromatic hydrocarbons (PAHs) and derivatives. Their toxicological effects were evaluated through oxidative potential (OP), cytotoxicity, and reactive oxygen species (ROS) generation in the human bronchial epithelial cell line BEAS-2B. The results reveal significant seaso

SUBMITTER: Ding Z 

PROVIDER: S-EPMC12945179 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature