Safety of Sabin Inactivated Poliovirus Vaccine Administered Standalone or Concomitantly with Other Childhood Vaccines: A Real-World Study in China.

ABSTRACT: Background/Objectives: Sabin strain-based inactivated poliovirus vaccine (sIPV) is increasingly used in China's routine immunization program and is often administered concomitantly with other childhood vaccines. However, large-scale real-world evidence on the safety of concomitant sIPV vaccination remains limited. This study evaluated the safety of sIPV administered standalone or concomitantly with other routine vaccines using provincial surveillance data. Methods: A retrospective observational study was conducted using data from the China National Adverse Events Following Immunization Surveillance System and the Anhui Provincial Immunization Information Management System. All sIPV doses administered between 1 November 2023 and 31 July 2025 were included. AEFI reporting rates

SUBMITTER: Wang B 

PROVIDER: S-EPMC12945227 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature