Genomic characterization of Sabia virus in Brazil, 2019-2020: Implications for diagnostics, virus evolution, and receptor binding.

ABSTRACT: Between December 2019 and January 2020, two patients suspected of having severe yellow fever were admitted to a tertiary healthcare facility in São Paulo, Brazil, presenting with acute hemorrhagic syndrome and neurological alterations; both cases had fatal outcomes. Upon admission, both tested negative for yellow fever viral RNA, and Sabiá virus (SABV), a New World arenavirus, was identified as the causative pathogen. To date, only four humans naturally acquired SABV infections have been confirmed, all fatal and linked to rural settings. We applied next-generation sequencing to generate complete and near-complete genomes from two patients (SP17 and SP19). Existing molecular diagnostics failed to detect SABV; therefore, new molecular tests were developed. Genetic analyses of SP17 and SP19 g

SUBMITTER: Claro IM 

PROVIDER: S-EPMC12945313 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature