Gut microbiota and metabolic pathway profiles in infected and non-infected heart transplant patients before and after surgery.

ABSTRACT: The composition and metabolic characteristics of gut microbiota in heart transplant patients with and without preoperative and postoperative infection were investigated to elucidate the impact of antibiotics and immunosuppressants. Twenty patients undergoing allogeneic heart transplantation were enrolled. Gut microbiota profiles were analyzed via 16 S rRNA gene sequencing and metabolic pathway prediction (PICRUSt2) at 5-9 days preoperatively and 30 days postoperatively. Patients were categorized into preoperative non-infected (Pre-NI), preoperative infected (Pre-I), postoperative non-infected (Post-NI) and postoperative infected (Post-I) groups for comparative analysis. Alpha/beta diversity, Maaslin and functional analyses were performed. Preoperative microbiota had similar α-diversity ind

SUBMITTER: Han J 

PROVIDER: S-EPMC12946200 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature