Stenotrophomonas promotes gastrointestinal tumor progression via STING degradation in tumour cells and mitigated immune response.

ABSTRACT: While numerous studies have reported that intratumor bacteria modulate tumor biological characteristics and therapeutic outcomes, the role of intracellular bacteria in gastrointestinal tumor (GIT) progression remains largely unexplored. Here, we show, through bioinformatics prediction and consecutive patient sample validation, that Stenotrophomonas is associated with tumor progression and poor prognosis in GIT. Using various murine tumor models, we find that intracellular Stenotrophomonas promotes GIT progression by decreasing IFNβ secretion and inhibiting MHC-II⁺ macrophages, thereby impairing the activity of effector CD8⁺ T cells. Mechanistically, Stenotrophomonas entry into tumor cells induces endoplasmic reticulum stress, degrades STING protein, and downregulates

SUBMITTER: Feng H 

PROVIDER: S-EPMC12946332 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature