A study on the correlation between DNA methylation and protein expression levels of <i>SDC2</i> in patients with colorectal cancer and its clinicopathological significance.

ABSTRACT: PurposeTo investigate the association between Syndecan-2 gene methylation and protein expression dynamics in colorectal cancer and evaluate its clinicopathological significance.MethodsWe analyzed 197 tissues (96 colorectal cancer, 64 adenoma, and 37 normal tissues). Syndecan-2 methylation was quantified using quantitative methylation-specific polymerase chain reaction, and protein expression was evaluated via immunohistochemistry.ResultsSyndecan-2 methylation frequency was significantly higher in colorectal cancer (81.25%) and adenoma (64.06%) than in normal (5.41%) tissues. It showed high diagnostic accuracy for colorectal cancer (area under the curve = 0.88). Although methylation status was unrelated to most clinical parameters, higher methylation levels were correlated with poor tumor d

SUBMITTER: Han Y 

PROVIDER: S-EPMC12946428 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature