Persisting Transglutaminase 6 Antibodies in Neurological Gluten-Related Disorders.

ABSTRACT:

Objective

Gluten-related autoimmunity can cause neurological disease, although the best way to diagnose and monitor such patients is unclear. Serological testing for antibodies against transglutaminase 6 (TG6) has been proposed; however, this is not widely available in clinical practice. Using longitudinal data from patients attending a specialist neurological center with routine TG6 testing, this observational study explores how antibody history relates to brain atrophy, cognition, and quality of life.

Methods

Serological records of patients with gluten-related neurological disease were collected alongside clinical brain magnetic resonance imaging. Patients were recruited to undertake questionnaires that assessed/included chronic symptom severity, the hospital anxiety and d

SUBMITTER: Croall ID 

PROVIDER: S-EPMC12946592 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature