Disease Progression in Multiple System Atrophy: The ASPIRE Multi-Modal Biomarker Study.

ABSTRACT:

Objective

The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression.

Methods

This 1-year, multicenter, prospective study assessed clinical, neuroimaging (3T-magnetic resonance imaging [MRI], dopamine transporter single-photon emission computed tomography [DaT-SPECT]), and neurofilament light chain (NfL) changes in patients with early MSA (< 5 years from symptom onset) and healthy controls (HCs). Clinical and biomarker changes from baseline to 6 months (M6) and 12 months (M12) were analyzed. Survival status was collected at 24 months. Mixed linear regression analyzed repeated measures, whereas univariate regression identified biomarkers linked to progression. Sa

SUBMITTER: Fabbri M 

PROVIDER: S-EPMC12946593 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature