Prevalence and Risk Factors of Elevated Alanine Aminotransferase (ALT) in 2382 Treatment-naive HBV/HDV Co-Infected Patients.

ABSTRACT:

Background

Chronic hepatitis D (CHD) causes severe chronic hepatitis. Knowledge is limited about factors correlating with ALT in treatment-naïve patients with CHD. This study analysed the pattern and determinants of ALT elevation in a large cohort of patients with CHD, including young adults, compared to propensity score-matched (PSM) patients with chronic hepatitis B (CHB).

Methods

We identified 2382 treatment-naïve HBsAg+ adults with CHD (HDV RNA positive) and 1553 with CHB attending a liver center in Mongolia during 2015-2023. The correlation between ALT levels, virological, biochemical, and fibrosis parameters was assessed using Spearman coefficient (rho). Logistic regression analysis was used to identify determinants of elevated ALT in 1371 PSM pairs with CHD and CHB ma

SUBMITTER: Kamal H 

PROVIDER: S-EPMC12946601 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature