Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan.

ABSTRACT: The operation of the human brain relies on functional networks enabled by inter-areal oscillatory synchronization between neuronal populations. Although disruptions in this functional connectivity are associated with brain disorders, evidence on its healthy age-dependent variation and behavioral relevance remains limited. Utilizing magnetoencephalography (MEG) recordings from 576 adults aged 18-87 years, we investigated the evolution of resting-state functional connectivity (rs-FC) across the healthy adult lifespan. We observed age-related, frequency-specific changes in widespread cortical networks. Alpha-band (8-13 Hz) rs-FC decreased, while delta (1-4 Hz), theta (4-8 Hz), and gamma-band (40-90 Hz) rs-FC increased with age. Beta-band (13-30 Hz) rs-FC followed a non-linear trajectory, peak

SUBMITTER: Ruuskanen S 

PROVIDER: S-EPMC12946715 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature