The Effects of Gut Microbiota, Plasma Metabolites, Immune Cells, Blood Cells and Cytokines on Schizophrenia: A Bidirectional Two-Sample Mendelian Randomisation Study.

ABSTRACT:

Background

The aberrant traits of the gut-metabolite-immune network in schizophrenia imply a crucial interrelationship among them. The exploration of the association between the gut-metabolite-immune network and schizophrenia will create novel opportunities for future studies on the disorder.

Methods

This study utilised the Mendelian randomisation (MR) method to examine the causal relationships among gut microbiota, plasma metabolites, immune cells, blood cells, cytokines and schizophrenia. Additionally, mediation analysis was performed to identify and verify potential mediators involved in the pathway linking gut microbiota to schizophrenia.

Results

A total of 62 traits with causal connections to schizophrenia were identified from the gut microbiota, plasma metabolit

SUBMITTER: Zhang K 

PROVIDER: S-EPMC12946721 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature