Matching heterogeneous cohorts by projected principal components reveals two novel Alzheimer's disease-associated genes in the Hispanic population.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is the most common form of dementia. Studies have suggested prevalence is greater in individuals self-identifying as Hispanic. Population-specific results enable personalized and equitable interventions. Ethnicity as a stratifier co-occurs with genomic inflation due to heterogeneity.

Methods

We conducted genome-wide association studies (GWAS) and meta-analyses among subjects from the Alzheimer's Disease Sequencing Project (ADSP) Umbrella whole genome sequencing (WGS) dataset who self-identified as Hispanic and All of Us (AoU) sub-cohorts matched to that cohort, using projected genetically-derived principal components.

Results

We identified a common variant in PIEZO2 on chromosome 18 protective for AD in ADSP subjects, with a p-val

SUBMITTER: Willett JDS 

PROVIDER: S-EPMC12946819 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature