Efficacy and Recovery of Remimazolam Versus Midazolam in Sedated Colonoscopy: A Multicenter Randomized Controlled Trial in Japan.

ABSTRACT:

Objectives

Sedation during colonoscopy is becoming increasingly important. Remimazolam, an ultra-short-acting benzodiazepine, has a shorter pharmacokinetic half-life than that of midazolam. This study examined whether remimazolam provides superior sedation during colonoscopy in Japanese patients.

Methods

This prospective, multicenter, randomized, single-blind, controlled trial included adults (18-80 years) scheduled for sedated colonoscopy. Participants were randomized to the remimazolam and midazolam groups. The primary outcome was the proportion of ambulatory patients 5 min after colonoscopy. Secondary outcomes were successful pre-procedure sedation (Modified Observer's Assessment of Alertness/Sedation [MOAA/S] ≤ 4), recovery time, total sedative dose, and adverse events.<

SUBMITTER: Yamaguchi D 

PROVIDER: S-EPMC12946854 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature