Quantifying uncertainty in calibration and clinical application of EBT-4 Gafchromic film dosimetry.

ABSTRACT:

Background

GAFchromic films (GAFs) are essential tools in radiotherapy dosimetry, but uncertainties in calibration methods limit their accuracy and hinder consistency across clinical practice.

Purpose

This study aimed to perform a comparative analysis of different calibration functions for GAFchromic EBT4 films in single- and double-channel dosimetry to quantify the uncertainty associated with their calibration and clinical use.

Methods

GAFchromic EBT4 films were irradiated to doses between 0.2 and 10 Gy using a 6 MV photon beam. A custom irradiation setup in a water-equivalent phantom ensured reference conditions, with dose verified by an ionization chamber. Films were scanned on an Epson Expression 13000XL flatbed scanner at 72 dpi, with pre- and postirradiation sca

SUBMITTER: Lombardi R 

PROVIDER: S-EPMC12947056 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature