Amerindian ancestry and extended longevity in Nicoya, Costa Rica.

ABSTRACT:

Objectives

The aim of this study was to address the hypothesis that Amerindian ancestry is associated with extended longevity in the admixed population of Nicoya, Costa Rica. The Nicoya Peninsula of Costa Rica has been considered a "longevity island," particularly for males.

Methods

We estimated Amerindian ancestry using 464 ancestral informative markers in 20 old Nicoyans aged ≥99 years, and 20 younger Nicoyans (60-65 years). We used logistic regression to estimate odds ratio (OR) and 95% confidence interval (CI) of the association of Amerindian ancestry and longevity.

Results

Older Nicoyans had higher Amerindian ancestry compared to younger Nicoyans (43.3% vs 36.0%, P = .04). Each 10% increase of Amerindian ancestry was associated with more than twice the odds of be

SUBMITTER: Azofeifa J 

PROVIDER: S-EPMC12947134 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature