Continuous monitoring of glutamate using electroactive templated polymers as synthetic molecular receptors.

ABSTRACT: Selective and spatiotemporally resolved monitoring of glutamate in the brain is essential for understanding its role in many brain functions as well as in the progression of various mental disorders. However, achieving accurate time resolved glutamate detection has been challenging due in part to the lack of glutamate-binding receptors that can offer both target selectivity and continuous measurement capability. To address this challenge, we have developed a novel polymer-based electrochemical biosensor designed to enhance selectivity for glutamate. Our proposed biosensor incorporates an innovative templated polymer-based target receptor, which selectively binds to the glutamate molecule. Furthermore, the reversible binding kinetics enable continuous glutamate detection with a time resolut

SUBMITTER: Motallebzadeh S 

PROVIDER: S-EPMC12947234 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature