Metabolomic identification and analysis of potential biomarkers of febrile seizures.

ABSTRACT:

Background

Febrile seizures (FS) represent the most common type of seizures in children; however, their exact pathogenesis remains incompletely understood. Currently, there is a lack of specific biomarkers for predicting FS occurrence, and existing prophylactic drug strategies remain controversial. Using untargeted metabolomics, this study investigates metabolic differences between children with FS and those with fever but without seizures (non-febrile seizures, NFS), aiming to elucidate the metabolic profile of FS and identify potential biomarkers, thereby providing new insights for clinical prediction and treatment.

Methods

Plasma samples were collected from 31 children with FS and 31 children with NFS. Untargeted metabolomic profiling was performed using high-performance

SUBMITTER: Tang H 

PROVIDER: S-EPMC12947323 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature