Cellularity habitat-based MRI radiomics for non-invasive grading and IDH mutation prediction in adult-type diffuse glioma.

ABSTRACT:

Background

Magnetic resonance imaging (MRI) radiomics has shown promise in glioma grading and isocitrate dehydrogenase (IDH) mutation prediction, but traditional whole-tumor approaches overlook intratumoral heterogeneity, limiting diagnostic accuracy and interpretability. This study aims to explore cellularity habitat-based MRI radiomics for precise grading and IDH mutation status prediction in adult-type diffuse glioma (ADG).

Methods

A total of 625 ADG patients were retrospectively collected. Whole-tumor volumes of interest (VOIs) were delineated on four conventional MRI sequences (T1WI, T2WI, T2-FLAIR, and CE-T1WI) and segmented into three cellularity habitats using apparent diffusion coefficient (ADC)-based K-means clustering: H₁ (low ADC), H₂ (mediu

SUBMITTER: Liang F 

PROVIDER: S-EPMC12947392 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature