Demographic, clinical, and immunological features in combined immunodeficiency patients: a comparative analysis of those with and without pulmonary manifestations - a multicenter study from Iran.

ABSTRACT:

Background

Combined immunodeficiency (CID) involves profound defects in B and T lymphocyte development and function. This study examined clinical and immunological phenotypes of CID patients with and without pulmonary manifestations.

Methods

This retrospective multicenter study included 53 CID patients diagnosed between 2009 and 2022 with available thoracic computed tomography scans. Patients were categorized based on pulmonary manifestations presence. Demographic, clinical, and laboratory characteristics were compared using conservative statistical thresholds (P < 0.01). All laboratory parameters were interpreted using age-adjusted pediatric reference ranges.

Results

Among 53 patients (56.6% male), 43 had pulmonary abnormalities on HRCT. Common clinical features incl

SUBMITTER: Khanbabaee G 

PROVIDER: S-EPMC12947537 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature