Integrated Representations of Threat and Controllability in the Lateral Frontal Pole.

ABSTRACT: Emotional processing is ubiquitous in everyday life, informing goal pursuit not only in response to current demands but also in anticipation of future outcomes. Lateral pFC (LPFC) function supports cognitive control, and emerging evidence suggests a unique role for its anterior-most region-the lateral frontal pole (FPl)-in integrating putatively amygdala-originated emotion signals with goal information. However, whether these organizational properties of LPFC are expressed during the anticipation of future threat remains unknown. Here, we used finite impulse response modeling and pattern similarity analysis to examine dynamic engagement and representational properties of distinct LPFC regions during threat anticipation requiring goal-directed action. Healthy participants (n = 67, 51 female

SUBMITTER: Stasiak JE 

PROVIDER: S-EPMC12948140 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature