Microfluidic Electrochemical Biosensor for the Detection of Platelet Factor 4 Antibody-Mediated Thrombotic Disorders.

ABSTRACT: Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a new disorder that emerged in the wake of coronavirus disease 2019 (COVID-19) vaccination. It is a rare but life-threatening condition that requires an aggressive course of treatment to improve patient outcomes. Currently, the diagnosis of VITT relies on a comprehensive panel of criteria, including a history of recent vaccination, platelet count, positive enzyme linked immunosorbent assays (ELISA) result for a closely related thrombotic disorder, heparin-induced thrombocytopenia (HIT), and platelet factor 4 (PF4)-dependent functional assays. The study describes a technically simple antigenic assay designed to detect autoimmune antibodies associated with VITT. It is first shown that cross-linked platelet factor 4 (c-PF4) represen

SUBMITTER: Cedillo-Alcantar DF 

PROVIDER: S-EPMC12948190 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature