Higher-Level Structural Classification of Pseudomonas Cyclic Lipopeptides through Their Bioactive Conformation.

ABSTRACT: Cyclic lipodepsipeptides (CLiPs) from Pseudomonas are membrane-targeting specialized metabolites with diverse ecological roles and antimicrobial activities. Over the past decades, significant efforts have been made to reveal their chemical constitution and configuration, thus providing the starting point to establishing structure-function correlations, deriving molecular-level understanding of their mode of action, and ultimately harnessing their potential in plant biocontrol and clinical applications. The sheer diversity in chemical structures, combined with a few scattered reports of 3D structures, has limited advances in these areas. The solution conformations of eight antimicrobial, non-phytotoxic Pseudomonas CLiPs, each representing a distinct family, are presented, obtained using a c

SUBMITTER: Kovacs B 

PROVIDER: S-EPMC12948218 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature