PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O-GlcNAcylation in Mice.

ABSTRACT: Perfluorooctane sulfonate (PFOS) is of great concern due to its accumulation in living organisms and reproductive toxicity. Although prior studies indicate that PFOS exposure causes female reproductive disorders, the underlying mechanism remains obscure. This study investigates the molecular mechanisms underlying PFOS-induced female reproductive toxicity at human-relevant exposure levels. These results demonstrate that PFOS exposure (0.2 and 20 µM) significantly reduces polar body extrusion (PBE) and delays germinal vesicle breakdown (GVBD) in oocytes. Additionally, PFOS exposure (1 mg kg^-1 day^-1) decreases the proportion of two-cell embryos and reduces progesterone (P4) levels. Elevated O-GlcNAcylation levels are observed in both ovaries and granulosa cells (GCs) und

SUBMITTER: Han S 

PROVIDER: S-EPMC12948240 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature