Notch2 Directs aTreg Cell Fate Toward Immunoregulation or Inflammatory Pyroptosis.

ABSTRACT: Activated regulatory T cells (aTregs) exhibit potent immunosuppressive functions and can migrate to tissues, playing a crucial role in attenuating inflammatory responses. The precise role and molecular mechanisms through which Notch2 regulates the immunoregulatory functions of aTregs remain incompletely elucidated. Here, we elucidate the mechanisms through which Notch2 influences aTreg dynamics and mitigates allergic rhinitis (AR) development. Mechanistically, the targeted knockout of Notch2 in aTregs resulted in decreased Foxo1 expression and elevated phosphorylated ASC (p-ASC) levels, culminating in GSDMD-N-mediated pyroptosis in aTregs. Moreover, the Notch2 intracellular domain (NICD2) promoted the nuclear translocation of RREB1 through direct protein-protein interactions, thereby enhan

SUBMITTER: Qiao YL 

PROVIDER: S-EPMC12948270 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature