Exploration of Therapeutic Targets Using CDK4 Inhibitors for Head and Neck Mucosal Melanoma.

ABSTRACT:

Objective

Mucosal melanoma (MM) is an extremely aggressive malignant tumor in the head and neck region associated with a poor prognosis. In the present study, we conducted cell proliferation assay and western blotting using cell lines derived from MM and the immunohistochemical analysis of pathological MM tissues to identify novel therapeutic targets. Herein, we report on the potential of cyclin-dependent kinase 4 (CDK4) inhibitors as molecular targeted therapies for MM.

Study design

Retrospective cohort study and laboratory analysis.

Setting

A tertiary referral center.

Methods

MTT assay and western blotting were performed on the HMV-II (RCB0777) and GAK (JCRB0180) cell lines, treated with the CDK4 inhibitors abemaciclib (LY2835219) and palbociclib (PD-0332991)

SUBMITTER: Hattori T 

PROVIDER: S-EPMC12948400 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature