Acute nutritional ketosis during early recovery from aerobic exercise does not affect skeletal muscle transcriptomic response in humans.

ABSTRACT:

Purpose

Nutritional ketosis is purported to enhance skeletal muscle recovery and adaptation to exercise, yet precise adaptive mechanisms are unknown. We investigated the post-exercise molecular response to ketone monoesters (KME) in skeletal muscle by characterising the early transcriptomic response.

Methods

Following a randomised, double-blind, crossover design, recreationally active men (n = 9, age: 26 ± 5 (means ± SD) y; V̇O_2max: 47 ± 4 mL·kg^-1·min^-1) completed two experimental trials where they ingested either 1.25 g·kg^-1 of KME or a taste-matched placebo (PLA) drink during exercise (90-min cycling at 60% of V̇O_2max) and 3-h recovery. Blood samples were taken throughout for hormone and metabolite analyses, and muscle

SUBMITTER: Mosquera-Lopez E 

PROVIDER: S-EPMC12948831 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature