A plasma metabolomic fingerprint of moderate or severe hearing loss.

ABSTRACT:

Background

Disabling hearing loss affects millions of adults world-wide. Metabolomics investigations are comprehensive assessments of an individual's metabolic processes that could provide insight into biological pathways underlying auditory dysfunction, yet data are limited.

Methods

We conducted a cross-sectional investigation of the association of plasma metabolite profiles and self-reported adult-onset moderate or severe hearing loss among 3925 women, including 1167 hearing loss cases and 2758 controls in the Nurses' Health Study. Information on hearing status at the time of the blood collection and on relevant risk factors was collected on biennial questionnaires. Metabolic profiling was conducted by liquid chromatography-mass spectrometry. The independent associations o

SUBMITTER: Li Y 

PROVIDER: S-EPMC12948882 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature