Dataset Information
Mechanical Stiffness Influences the Response of Human Uterine Fibroid Cells to Hormonal Treatments.
Ontology highlight
ABSTRACT:
SUBMITTER: Bariani MV
PROVIDER: S-EPMC12948898 | biostudies-literature | 2026 Jan
REPOSITORIES: biostudies-literature
Publications
Mechanical Stiffness Influences the Response of Human Uterine Fibroid Cells to Hormonal Treatments.
Reproductive sciences (Thousand Oaks, Calif.) 20251208 1
Uterine fibroids (UFs), the most common gynecologic tumors in reproductive-age women, are characterized by the accumulation of extracellular matrix (ECM), which leads to increased stiffness. The stiffness can transfer mechanical signals from the ECM to the intracellular environment through a process called mechanotransduction, consequently altering the biological behavior of the cell. UFs are estrogen and progesterone-dependent, with hormonal fluctuations influencing their growth and development ...[more]