Treatment adherence and clinical outcomes of osimertinib in minority patients with advanced EGFR mutated NSCLC.

ABSTRACT: Osimertinib has been one of the most commonly prescribed first-line treatments for EGFR-mutated advanced NSCLC for the last several years for patients with EGFR-mutated non-small cell lung cancer (NSCLC), yet clinical outcomes among racial and ethnic minority patients remain poorly characterized due to underrepresentation in pivotal trials. We conducted a retrospective study of 174 patients with advanced EGFR-mutated NSCLC treated at the Montefiore Einstein Comprehensive Cancer Center (MECCC) from 2015 to 2024 to evaluate real-world survival and treatment adherence. The cohort included 32.2% Hispanic, 28.7% non-Hispanic Black (NHB), 26.4% non-Hispanic White (NHW), and 12.6% Asian patients. In multivariable analyses, NHB patients experienced significantly worse overall survival compared wit

SUBMITTER: Lee M 

PROVIDER: S-EPMC12948958 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature