Evaluation of immuno-oncologic biomarkers and β-catenin expression in response of hepatocellular carcinomas to immunotherapy.

ABSTRACT: Immune checkpoint inhibitors (ICIs) are utilized to treat hepatocellular carcinomas (HCC) without validated biomarkers. We sought to identify genomic signatures and immune patterns predicting treatment efficacy in 1,306 HCC patients to evaluate for potential predictive biomarkers associated with immunotherapy outcome. Programmed death ligand 1 (PD-L1) expression was high in 6.1% and low in 11.6%; deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H) was detected in only 0.2%, and high tumor mutational burden (TMB-H) in 5.1% of the patients. Immuno-oncologic (IO) markers (CD80, HAVCR2, PDCD1, IFNG, CTLA4, IDO1, CD86, LAG3, PDCD1LG2) correlated with PD-L1 expression (q < 0.05). Infiltration of B cells, M1 macrophages, CD8 + T cells, and T_regs also increased with P

SUBMITTER: Sharma G 

PROVIDER: S-EPMC12948995 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature