Continuous carbon dioxide monitoring in the exhaled breath of mechanically ventilated rats.

ABSTRACT: In small animals, carbon dioxide monitoring is either limited by the need to take blood samples for gas analysis, or it interferes with respiratory efficiency and lung mechanics analysis. We introduced a novel approach for continuous monitoring of CO₂ in the expiratory limb of the breathing circuit. The relevance of the method is assessed by CO₂ measurements at different respiratory settings. Rats were ventilated with a tidal volume (V_T) of 8 mL kg^-1. Respiratory rates were adjusted to achieve arterial CO₂ partial pressure ( PaCO2${P_{{\mathrm{aC}}{{\mathrm{O}}_2}}}$ ) between 35 and 45 mmHg. We measured partial pressure of CO₂ in the expiratory limb of the breathing circuit (exCO₂). exCO₂ values were c

SUBMITTER: Wenzel C 

PROVIDER: S-EPMC12949111 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature