Cognitive and emotional effects of bilateral prefrontal anodal tDCS and high-frequency tRNS in schizophrenia: a randomized sham-controlled study.

ABSTRACT: Cognitive deficits in schizophrenia significantly hinder functional outcomes and often remain unresponsive to conventional treatments. While initial evidence suggested potential pro-cognitive effects of electrical brain stimulation in schizophrenia, recent meta-analyses have not supported these findings, warranting further investigation on intervention optimization. This sham-controlled crossover study explored cognitive and emotional effects of bilateral dorsolateral prefrontal cortex (DLPFC) anodal transcranial direct current stimulation (tDCS) and high-frequency transcranial random noise stimulation (tRNS) in schizophrenia. Thirty-six male patients with schizophrenia participated in a crossover trial, receiving three sessions (tDCS, tRNS, sham) in counterbalanced order with 1-week inter

SUBMITTER: Jafari E 

PROVIDER: S-EPMC12949120 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature