Predicting Cochlear Synaptopathy in Mice with Varying Degrees of Outer Hair Cell Dysfunction Using Auditory Evoked Potentials.

ABSTRACT:

Purpose

Although human temporal bones suggest that cochlear synapse numbers decline with age and noise exposure, no validated diagnostic method exists. In animal models, cochlear synaptopathy is associated with reduced auditory brainstem response (ABR) wave 1 amplitude and envelope following response (EFR) magnitude for a sinusoidally amplitude modulated (SAM) tone. However, measuring SAM EFR at the optimal modulation frequency (1000 Hz) is difficult in humans. A rectangular amplitude modulated (RAM) tone may be more sensitive to synaptopathy, but this has not been validated in animals. In addition, because synaptopathy likely co-occurs with outer hair cell dysfunction (OHC), a diagnostic assay needs to be robust to abnormal auditory thresholds. The objective of this study was to e

SUBMITTER: Buran BN 

PROVIDER: S-EPMC12949156 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature