A novel signature of palmitoylation for predicting prognosis and therapeutic response of hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) represents an extremely complex and heterogeneous malignant tumor. Protein palmitoylation, a highly conserved and pivotal form of post-translational protein modification, is extensively implicated in cancer progression and exerts a regulatory role in immune responses. Nevertheless, the prognosis significance and therapeutic potential of palmitoylation-related genes (PRGs) in HCC remain incompletely explored. In the present study, we systematically analyzed multiple transcriptome cohort samples from the TCGA, ICGC and GEO databases, including the TCGA-LIHC, ICGC-LIRI, GSE16757, GSE54236, GSE14520, GSE45267 and GSE36376 cohorts. Subsequently, within the TCGA training cohort, a PRGsSig comprising three hub PRGs, namely HSP90AA1, CTHRC1, and PTDSS2, was construct

SUBMITTER: Li Y 

PROVIDER: S-EPMC12949217 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature