Multicenter Prospective Validation of an Updated Proprietary Sepsis Prediction Model.

ABSTRACT:

Importance

The Epic Sepsis Model version 2 (ESM v2) is a widely implemented proprietary sepsis prediction model, but no multicenter, external validation of its performance has been reported to guide adoption and use.

Objective

To conduct a multicenter validation of the ESM v2 to compare performance against the original ESM v1, outline differences across heterogenous clinical sites, and compare model performance against clinician recognition of sepsis.

Design, setting, and participants

This prognostic study included adult inpatient encounters at 4 large US health systems between August 31, 2023, and March 11, 2025. At each site, data were collected for a consecutive period immediately following new model implementation. Data were analyzed from July 23 to August 19, 202

SUBMITTER: Wong A 

PROVIDER: S-EPMC12949446 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature