Asynchronous firing and off states in working memory maintenance.

ABSTRACT: Persistent spiking activity and activity-silent mechanisms have been proposed as neural correlates of working memory. To determine their relative contribution, we recorded neural activity from the lateral prefrontal and posterior parietal cortex of two male macaques using high-density microelectrode probes. We found that, when averaged across all neurons, persistent delay activity was observable throughout the duration of single trials in populations of prefrontal neurons with silent periods that did not deviate significantly from chance. However, temporal fluctuations in activity-dependent mnemonic information were present and weakly correlated between the prefrontal and posterior parietal cortices, suggesting at least partial, long-distance synchronization of off states. The decoding acc

SUBMITTER: Mozumder R 

PROVIDER: S-EPMC12949571 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature