Emicizumab in the treatment of acquired hemophilia A: A Two-Center experience.

ABSTRACT: Emicizumab is a FVIII mimetic antibody used in the treatment of inherited hemophilia A that could potentially be used in acquired hemophilia A (AHA) to achieve hemostasis and shorten hospital stay while reducing bypass therapies. We report on 12 cases of AHA patients treated with emicizumab in an academic center between January 2020 and June 2024. There were 5 male and 7 female patients, with median (interquartile range [IQR]) age and maximum inhibitor titer of 73 (60-76) years and 138 (36.75 -164.25) BU/mL, respectively. Ten patients were started on emicizumab while admitted inpatient, while 2 were started outpatient. The initial emicizumab dose was 3 mg/kg for 8 patients and 1.5 mg/kg for 4 patients; all patients then continued therapy with emicizumab 1.5 mg/kg every other week starting

SUBMITTER: Su M 

PROVIDER: S-EPMC12950042 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature